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Herpes-simplex-virus(HSV)DNA in cerebrospinal fluid was amplified by use of the polymerase chain reaction and identified by hybridisation to a specific oligonucleotide probe.Specimens of cerebrospinal fluid(CSF)from 4 of 4 patients with herpes simplex encephalitis were positive for HSV DNA, whereas CSF specimens from 6 patients with other central-nervous-system infections were negative.This technique may expedite diagnosis of herpes simplex encephalitis. |
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